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Results for " HY-10261B " in MedChemExpress (MCE) Product Catalog:

Inhibitors & Agonists

Cat. No. Product Name Target Research Area
  • HY-10261B
    (E/Z)-Afatinib Autophagy; p38 MAPK; Akt; c-Met/HGFR; Apoptosis; EGFR Others
    (E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells[1].

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